So, you’ve been trying to conceive, and it’s not happening as quickly as you hoped. Maybe you’ve scrolled through endless forums, heard conflicting advice from well-meaning friends, or even felt a quiet worry creeping in: “Is something wrong with me?” Let me start by saying this: You’re not alone. Thousands of women navigate this uncertainty every year, and there’s nothing to feel ashamed about.
At Proactive For Her, we’ve supported countless women like you on their conception journey. Today, let’s demystify IUI (intrauterine insemination), a fertility treatment that might be your next step. No jargon, no judgment—just clear, science-backed insights to help you feel calm and in control.
What is IUI (intrauterine insemination)?
IUI is a simple, non-invasive fertility treatment where sperm is placed directly into your uterus during ovulation. Think of it as giving nature a gentle nudge—it boosts the chances of sperm meeting the egg without invasive procedures. Unlike IVF (which involves fertilising eggs outside the body), IUI works with your natural cycle.
Why is IUI Performed?
Mild male infertility
When sperm count or motility is a bit low, IUI “washes” and concentrates the healthiest swimmers, then places them directly into the uterine cavity giving you a better shot at fertilization without jumping straight to IVF.
Unexplained infertility
If standard tests show no clear reason you’re not conceiving (affecting up to 25% of couples), IUI combined with mild ovarian stimulation can significantly boost your chances over doing nothing.
Ovulation issues (e.g., PCOS)
Conditions like PCOS and endometriosis often cause irregular cycles. By adding gentle medications to induce one or two mature follicles and timing insemination precisely, IUI helps sync sperm delivery with ovulation.
Same‑sex couples & single mothers (donor sperm)
Using screened donor sperm, IUI places it right when you’re most fertile—no at‑home guesswork.
When Should You Do IUI Treatment?
Not sure if IUI is for you? Let’s break down the most common reasons behind IUI:
1. After 6–12 Months of Trying Naturally
If you’re under 35 and haven’t conceived after a year (or 6 months if you’re over 35), IUI could help.
2. For Specific Medical Conditions
- Mild male factor infertility such as low sperm count or poor sperm motility.
- Unexplained infertility
- Endometriosis
3. When You Want a Low-Intervention Option
IUI is less invasive and more affordable than IVF and can be done both naturally or with fertility medications.
How Long is the IUI Process from beginning to end?
From start to finish, one IUI cycle takes 2–4 weeks:
- Days 1–14: Cycle monitoring to track ovulation.
- Day of Trigger Shot: A hormone injection (hCG) to time ovulation.
- Day of Procedure: Sperm is inserted into the uterus (takes 5–10 minutes!).
- The Two-Week Wait: Pregnancy test 14 days later.
IUI Treatment Process
Step 1: Tracking Your Fertile Window
“When exactly is the right time?”
This is where science meets your natural cycle. Over Days 3–12 of your menstrual cycle, we’ll use blood tests (to check hormone levels) or ultrasounds (to monitor follicle growth) to pinpoint ovulation. It’s like detective work for your fertility!
- Why? Timing is everything. We want to catch that golden 24–36 hour window when the egg is ready.
Step 2: The Trigger Shot
“Wait, an injection?!”
Yes, but it’s simpler than you think. If your body needs a little help ovulating on schedule, we’ll give you a quick hormone injection (hCG). It’s a tiny pinch (like a flu shot!). It helps us get the time of ovulation right.
- When? Usually 36 hours before the IUI procedure.
Step 3: Sperm Prep
In the lab, we gently separate healthy, active sperm from semen (removing chemicals or weak swimmers). This process is called sperm washing and leaves a super-concentrated sample of the best swimmers. The partner or donor will be asked not to have sex or masturbate before this process for at least 3-4 days.
Step 4: Insemination
“What actually happens?”
You’ll lie down (just like during a Pap smear), and a thin, flexible catheter will gently place the prepared sperm into your uterus.
- How long? 5–10 minutes tops.
- Aftercare: Rest for 15–30 minutes, then go about your day!
Around 14 days later, we’ll do a blood test to check for pregnancy.
What do you do to prepare for IUI treatment?
Preparing for an IUI (intrauterine insemination) starts with getting your body and mind in sync. Eat a balanced diet, take prenatal vitamins with folic acid, and avoid alcohol, smoking, or intense workouts—these small changes can make a big difference. Try and include eggs, leafy vegetables, dry fruits, nuts, seeds and oats in your diet. Your doctor will guide you through hormone tests, ultrasounds, and possibly ovulation medications to ensure timing is just right. If your cycle includes a trigger shot (to time ovulation), you’ll usually have the IUI about 36 hours later.
Your partner may be asked to abstain from ejaculation for 1–3 days before the sperm sample, which will be “washed” to select the healthiest sperm. Emotionally, this can be a lot- so take time to rest, talk things out, and lean on someone you trust. You're doing something strong and hopeful, and that deserves all the care and calm you can give yourself.
What happens after IUI treatment?
- Rest: Take it easy for 15–30 minutes post-procedure.
- Symptoms: Mild cramping, feeling of fullness or spotting is normal.
- Testing: Wait 14 days for a pregnancy test (yes, the wait is hard- we know!).
How much does IUI cost?
IUI costs between ₹5,000–₹15,000 per cycle in India, depending on medications and monitoring. You can approach us for a detailed cost breakdown and step-by-step explanation of the process.
What are the risks of IUI?
Ovarian Hyperstimulation Syndrome (OHSS): Rare, but possible if fertility drugs are used.
Infection: Very low risk (<1%).
Multiple Pregnancy: 8–10% chance of twins.
Source: Mayo Clinic
What are the most common side effects of IUI?
Let’s be real: Any medical procedure can feel nerve-wracking. But with IUI, side effects are usually mild and short-lived. Here’s what you might experience:
1. Light Cramping or Spotting
A little cramping (like period pains) or light spotting after the procedure is normal. It’s just your uterus adjusting- think of it as a temporary “Hey, what’s that?!” reaction.
2. Mild Pelvic Discomfort
The catheter used during insemination can cause fleeting pressure or discomfort. It typically fades within minutes to hours.
3. Bloating or Mood Swings
Only if fertility medications are used: Hormones like Clomid or Letrozole might cause bloating, headaches, or mood swings. Not everyone needs these drugs, though!
4. Rare Risks
Infection: Less than 1% chance (we use sterile tools, so this is super uncommon).
Ovarian Hyperstimulation Syndrome (OHSS): Rare and linked only to fertility drugs (not IUI itself). Symptoms like severe bloating or nausea warrant a call to your doctor.
The good news? Most side effects vanish within a day or two. If something feels “off,” trust your gut and reach out to your care team- no question is too small!
Source: American Society for Reproductive Medicine (ASRM), Mayo Clinic
Benefits of getting an IUI treatment
IUI (intrauterine insemination) is a gentle, low-intervention fertility treatment designed to work with your body’s natural cycle. Unlike more complex procedures like IVF, IUI is minimally invasive—no surgery or anaesthesia required—and typically involves shorter appointment times, making it easier to fit into busy schedules. It’s also more affordable, costing a fraction of IVF.
For couples facing challenges like mild male infertility (low sperm count or motility), irregular ovulation (e.g., due to PCOS), or unexplained infertility, IUI offers a hopeful first step. By placing washed, concentrated sperm directly into the uterus during ovulation, skips cervical barriers and boosts the chances of conception. While success rates vary, the process is less emotionally and physically taxing than IVF.
What is the success rate of IUI in India?
The chances of IUI working depend on factors like both partners’ ages, their overall fertility health, and whether fertility medications are used. When done monthly, the success rate can reach up to 20% per cycle.
Source: https://www.medicalnewstoday.com/articles/iui-procedure
What is the difference between IVF and IUI (intrauterine insemination)?
| Factor | IUI | IVF |
| Invasiveness | Low | High |
| Cost | ₹5K–₹15K per cycle | ₹1.5L–₹4L per cycle |
| Success Rate | 10–20% | 40–60% |
How can Proactive For Her help?
At Proactive For Her, we get it. Fertility journeys can feel lonely, but we’re here to walk with you:
- Personalised Care: Tailored cycle monitoring and gentle guidance.
- Stigma-Free Zone: No awkward questions, no judgment.
- Expert Team: OB-GYNs who listen and empower.
Seal of Her Approval
“After two years of anxiety, Proactive For Her made me feel heard. The IUI process was smooth, and my doctor explained every step. Today, I’m holding my baby girl.”
– Anonymous
Final Note: You’ve Got This!
If you’re considering IUI, you’re already taking charge by seeking answers- and that’s brave. Remember, there’s no “right” timeline for motherhood.
Whether you need clarity, support, or just a safe space to talk, Proactive For Her is here.
Book a consultation, and let’s navigate this journey together.
Medical Disclaimer: The information provided is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified healthcare provider before making any health decisions.
FAQ
How long does it take to know you are pregnant after IUI?
Wait at least 14 days after IUI before taking a pregnancy test. Testing earlier can result in false negatives (if hCG levels are too low) or false positives (if a trigger shot containing hCG was used, as it lingers in the body for ~14 days) 19. Blood tests at this time are more accurate than home urine tests.
How many cycles of IUI do you try before IVF?
Most clinics recommend 3–6 IUI cycles before moving to IVF, as ~90% of successful IUIs occur within 3–4 attempts. If no pregnancy occurs after 6 cycles, IVF is typically advised.
Is there anything I can do to increase my chances of pregnancy with IUI?
- Track ovulation precisely using OPKs or ultrasounds.
- Use fertility medications as advised by doctors (e.g., Clomid, Letrozole) to stimulate egg production.
- Maintain a healthy lifestyle: balanced diet, hydration, and stress reduction.
Is IUI better than IVF?
No—they serve different needs. IUI is less invasive, cheaper (₹5,000–₹15,000/cycle), and ideal for mild infertility or ovulation issues. IVF (₹1.5–₹4 lakhs/cycle) is more effective (40–60% success) for severe male infertility, blocked tubes, or genetic concerns.
Can I have sex after IUI?
Yes, but avoid it for 24–48 hours post-procedure to reduce infection risk. It doesn’t impact success rates.
How effective is IUI in getting pregnant?
Success rates range 10–20% per cycle for women under 35, dropping with age. Factors include sperm quality, ovulation regularity, and medication use.
How painful is IUI treatment?
Mild cramping or spotting may occur, but the procedure itself is quick (5–10 minutes) and comparable to a Pap smear.
What medications are used during IUI?
- Clomid/Letrozole: Stimulate ovulation.
- hCG trigger shot: Timed 24–36 hours before IUI to induce ovulation.
- Progesterone: Supports uterine lining post-IUI.
When is the optimal time to perform IUI?
24–36 hours after an LH surge or hCG trigger shot. For non-male infertility, post-ovulation timing is better; for male factor, double IUI (two inseminations in one cycle) may help.
How is ovulation monitored for IUI timing?
- Surge detection: At-home ovulation predictor kits (OPKs).
- Ultrasounds: Track follicle growth (18–20mm ideal).
- Blood tests: Measure estrogen and progesterone levels.
What role does the hCG trigger shot play in scheduling IUI?
The hCG shot triggers ovulation within 24–36 hours, ensuring precise timing for insemination. It synchronizes egg release with sperm placement.
Can IUI be performed during a natural ovulation cycle?
Yes, but success rates are lower (~10% vs. 15–20% with medications). A natural cycle may include an hCG trigger to time ovulation.
How does the timing of IUI affect success rates?
Correct timing is critical:
- Post-ovulation IUI improves success for non-male infertility.
- Double IUI may boost chances for male factor issues.
Is a single IUI sufficient, or should multiple inseminations be considered?
Most cases use single IUI, but double IUI (two procedures in one cycle) might increase pregnancy rates slightly, though studies show low-quality evidence.
How do fertility medications influence IUI timing?
Medications like Clomid or Letrozole control ovulation, allowing doctors to schedule IUI precisely. They also increase follicle count, raising pregnancy chances (and multiples risk).
What are the signs that indicate the best time for IUI?
- LH surge detected via OPKs.
- Ultrasound confirmation of mature follicles (18–20mm).
- Blood tests showing rising estrogen/progesterone.
How soon after detecting an LH surge should IUI be performed?
Within 24–36 hours of the LH surge or hCG trigger shot.
Are there risks associated with incorrect IUI timing?
Yes:
- Reduced pregnancy chances (sperm/egg miss each other).
- False positives if testing too early (due to residual hCG from trigger shots)